苄哒唑

概述生物活性体内研究苄哒唑试剂级价格

苄哒唑

CAS号:22994-85-0
英文名:Benznidazole
中文名:苄哒唑
CBNumber:CB9390906
分子式:C12H12N4O3
分子量:260.25
MOL File:22994-85-0.mol

苄哒唑化学性质

熔点 :189-192 °C (lit.)
密度 :1.35±0.1 g/cm3(Predicted)
储存条件 :Sealed in dry,Room Temperature
溶解度 :methanol: soluble50mg/mL, clear, colorless to yellow
酸度系数(pKa) :14?+-.0.46(Predicted)
形态 :Solid
颜色 :White to Off-White
水溶解性 :0.4g/L(temperature not stated)
Merck :13,1085
BCS Class :3

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26-36
WGK Germany :3
RTECS号 :NI3340000

苄哒唑性质、用途与生产工艺

概述苄哒唑可用作医药合成中间体。如果吸入苄哒唑，请将患者移到新鲜空气处；如果皮肤接触，应脱去污染的衣着，用肥皂水和清水彻底冲洗皮肤，如有不适感，就医；如果眼晴接触，应分开眼睑，用流动清水或生理盐水冲洗，并立即就医；如果食入，立即漱口，禁止催吐，应立即就医。
生物活性 Benznidazole (Radanil)是一种硝基咪唑衍生物，能够干扰寄生虫蛋白质的生物合成、影响其细胞因子的产生、刺激宿主的吞噬作用，因而具有抗原虫活性。

体内研究

Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart, in mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate and treated at 180 days post infection (p.i.) (i.e. chronic phase) with Benznidazole.

Animal Model:	Mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12
Dosage:	100 mg/kg/day
Administration:	Orally for 30 days
Result:	Produced a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart.