促食素A

生物活性体外研究体内研究促食素A 试剂级价格

促食素A

CAS号:205640-90-0
英文名:Orexin A (bovine, human, mouse, rat)
中文名:促食素A
CBNumber:CB9355020
分子式:C152H243N47O44S4
分子量:3561.1
MOL File:205640-90-0.mol

促食素A化学性质

密度 :1.53±0.1 g/cm3(Predicted)
储存条件 :-15°C
溶解度 :Soluble to 1 mg/ml in sterile
形态 :crystalline solid
颜色 :White to off-white
水溶解性 :Soluble in water at 1mg/ml
序列 :Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-IIE-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

安全信息

WGK Germany :3
海关编码 :2937190000

促食素A性质、用途与生产工艺

生物活性 Orexin A human, rat, mouse 是一种 33 氨基酸兴奋性神经肽，参与多种中枢和外周过程。Orexin A human, rat, mouse 是一种特异性、高亲和力的 G 蛋白偶联受体 OX1R 激动剂，在调节摄食行为中起重要作用。Orexin A human, rat, mouse 是一种有效的抗伤害和抗痛觉过敏的药物。
体外研究

Orexin A human, rat, mouse has high affinity for OX1R, with 38 nM IC ₅₀ and 34 nM EC ₅₀ values in the the [Ca ^2﹢ ]i transient assay.

体内研究

Orexin A human, rat, mouse (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively.
Orexin A human, rat, mouse (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg.

Animal Model:	Female mice (mouse carrageenan-induced thermal hyperalgesia test)
Dosage:	3, 10 and 30 mg/kg
Administration:	i.v.; 5 min pre-test
Result:	Significantly increased the latency to response at 10 and 30 mg/kg.