222318-55-0

CAS号:222318-55-0
英文名:Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 1-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-, 4-oxime, (4E)-
中文名:222318-55-0
CBNumber:CB93339704
分子式:C25H31FN4O3
分子量:454.5370432
MOL File:222318-55-0.mol

222318-55-0化学性质

222318-55-0性质、用途与生产工艺

生物活性 (4E)-SUN9221 是一种有效的 α1-adrenergic receptor 和 5-HT2 receptor 拮抗剂，具有抗高血压和抗血小板聚集的功效。
靶点

5-HT ₂ Receptor

α1
体外研究

(4E)-SUN9221 potently inhibits collagen-, ADP- and epinephrine-induced platelet aggregation, with IC ₅₀ s of 10 nM, 35 nM, 14 nM, respectively, in human platelet-rich plasma (PRP). (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22).
体内研究

(4E)-SUN9221 (1, 3, 10 mg/kg, p.o.) reduces the blood pressure in a dose-dependent manner in conscious spontaneously hypertensive rats (SHR). (4E)-SUN9221 (3 mg/kg) exhibits antihypertensive activity in SHR.

222318-55-0上下游产品信息

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下游产品

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