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荧光标记淀粉样蛋白肽(1-40)

荧光标记淀粉样蛋白肽(1-40),1678416-08-4,结构式
荧光标记淀粉样蛋白肽(1-40)
  • CAS号:1678416-08-4
  • 英文名:5-FAM-Amyloid β-Protein (1-40)
  • 中文名:荧光标记淀粉样蛋白肽(1-40)
  • CBNumber:CB93158644
  • 分子式:
  • 分子量:0
  • MOL File:Mol file

荧光标记淀粉样蛋白肽(1-40)性质、用途与生产工艺

  • 生物活性 β-Amyloid (1-40), FAM-labeled 是一个 FAM 荧光标记的 β-Amyloid (1-40) 肽 (λex= 492 nm and λem= 518 nm)。
  • 靶点

    λ ex = 492 nm; λ em = 518 nm

  • 体外研究

    Apical-to-basolateral exchange across endothelial monolayer of fluorescent Aβ42 (FAM-labeled Human β-Amyloid (1-42) and Fluor 488-labeled β-Amyloid (1-42)) or scramble Aβ42 ( FAM-labeled scrambled β-Amyloid (1-42) ) (1-100 μM) is monitored in transendothelial electrical resistance (TEER) during cell monolayer’s formation over time (over 120 min in presence or absence of Aβ24). Human β-Amyloid (1-24) (1 μM) results in H-Aβ42 retention, thus reducing its efflux through the BBB and therefore preventing an efficient mechanism of Aβ42 clearance.The in vitro BBB model is used to investigate the passage of FAM-labeled or 488-conjugated H-Aβ42 across the endothelial cell monolayer. The addition of fluorescently labeled H-Aβ42 (FAM-labeled Human β-Amyloid (1-42) or Fluor 488-labeled β-Amyloid (1-42)) to the apical side of cell inserts results in effective BBB crossing, FAM-labeled scrambled β-Amyloid (1-42) is not efficiently transcytosed.

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上游原料
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荧光标记淀粉样蛋白肽(1-40)生产厂家
  • 公司名称:Creative Peptides
  • 联系电话:
  • 电子邮件:info@creative-peptides.com
  • 国家:美国
  • 产品数:6083
  • 优势度:56
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