生物活性 靶点 体外研究 289479-94-3 试剂级价格
ChemicalBook  CAS数据库列表  289479-94-3

289479-94-3

289479-94-3,289479-94-3,结构式
289479-94-3
  • CAS号:289479-94-3
  • 英文名:TN1
  • 中文名:289479-94-3
  • CBNumber:CB93155072
  • 分子式:C29H31N7O2
  • 分子量:509.6
  • MOL File:289479-94-3.mol
289479-94-3化学性质
  • 密度 :1.31±0.1 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :DMSO : 100 mg/mL (196.23 mM);Water : < 0.1 mg/mL (insoluble)
  • 形态 :Solid
  • 酸度系数(pKa) :10.49±0.70(Predicted)
  • 颜色 :White to off-white

289479-94-3性质、用途与生产工艺

  • 生物活性 TN1 是一种有效的胎儿型血红蛋白 (HbF) 诱导剂。
  • 靶点

    fetal hemoglobin (HbF)

  • 体外研究

    A high-throughput screen of a large chemical library identifies a 2,6-diamino-substituted purine, TN1, which induces fetal hemoglobin (HbF) more potently than hydroxyurea in KU812 and K562 leukemia cell lines.TN1 increases HbF protein in both leukemic KU812 and K562 cells in a dose-dependent manner. At 100 nM concentration, Western blot analysis indicated that TN1 increased γ-globin expression (2.9- and 3.7-fold increase in KU812 cell and K562 cell, respectively) to higher levels than 50-100 μM HU (1.8- and 1.9-fold increase in KU812 cell and K562 cell, respectively), the first drug approved for the treatment of SCD. The EC 50 value for TN1-mediated HbF induction is approximately three orders of magnitude lower than that of HU (HU: EC 50 =50-100 μM; TN1: EC 50 =100 nM). In addition, TN1 is more potent than a number of previously reported small-molecule HbF inducers including sodium butyrate and other histone deacetylase (HDAC) inhibitors. At the concentrations tested, TN1, as well as hemin and HU, increase γ-globin mRNA transcription (greater than fourfold), indicating that TN1 increases γ-globin levels at both the transcriptional and protein level. The time course of TN1-induced γ-globin mRNA and protein synthesis is measured and both increase after approximately 24 h of treatment. TN1 also induces β-globin mRNA in addition to γ-globin mRNA, similar to hydroxyurea.

289479-94-3上下游产品信息
上游原料
下游产品
289479-94-3 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-100826
  • 产品名称:289479-94-3 TN1
  • CAS编号:289479-94-3
  • 包装:5mg
  • 价格:2900元
  • 更新日期:2024/11/08
  • 产品编号:HY-100826
  • 产品名称:289479-94-3 TN1
  • CAS编号:289479-94-3
  • 包装:10mM * 1mLin DMSO
  • 价格:3250元
289479-94-3生产厂家
  • 公司名称:Musechem
  • 联系电话:+1-800-259-7612
  • 电子邮件:info@musechem.com
  • 国家:美国
  • 产品数:4660
  • 优势度:60
  • 公司名称:TargetMol Chemicals Inc.
  • 联系电话:+1-781-999-5354 +1-00000000000
  • 电子邮件:marketing@targetmol.com
  • 国家:美国
  • 产品数:32161
  • 优势度:58
  • 公司名称:MedChemExpress
  • 联系电话:--
  • 电子邮件:sales@medchemexpress.com
  • 国家:美国
  • 产品数:6398
  • 优势度:58