GSK 2033

GSK 2033化学性质

储存条件 :2-8°C
溶解度 :DMF:5.0(Max Conc. mg/mL);8.45(Max Conc. mM)
DMSO:17.46(Max Conc. mg/mL);29.51(Max Conc. mM)
形态 :powder
颜色 :white to beige

GSK 2033性质、用途与生产工艺

生物活性 GSK2033 是一种 LXR 拮抗剂，对于 LXRα 和 LXRβ 的 pIC50 值分别为 7 和 7.4。
靶点

pIC50: 7 (LXRα), 7.4 (LXRβ)
体外研究

GSK2033 is a LXR antagonist with pIC ₅₀ s of 7 and 7.4 for LXRα or LXRβ, respectively. GSK2033 dose-dependently suppresses basal transcription in full-length LXRα or full-length LXRβ cotransfection assays with IC ₅₀ s of 17 nM and 9 nM, respectively. GSK2033 also effectively suppresses the transcription of an ABCA1 driven luciferase reporter dose-dependently displaying IC ₅₀ s of 52 nM for LXRα and 10 nM for LXRβ. GSK2033 also suppresses the expression of both of fatty acid synthase ( FASN ) and SREBP1 .
体内研究

One month treatment of GSK2033 does not have significant effects on hepatic triglyceride levels. Plasma triglyceride levels are also unaffected by treatment with GSK2033.

GSK 2033上下游产品信息

上游原料

下游产品

GSK 2033 试剂级价格

GSK 2033生产厂家

1221277-90-2, GSK 2033相关搜索: