生物活性 体外研究 体内研究 牛甲状旁腺激活素-(1-34) 试剂级价格
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牛甲状旁腺激活素-(1-34)

牛甲状旁腺激活素-(1-34),12583-68-5,结构式
牛甲状旁腺激活素-(1-34)
  • CAS号:12583-68-5
  • 英文名:PARATHYROID HORMONE (1-34), BOVINE
  • 中文名:牛甲状旁腺激活素-(1-34)
  • CBNumber:CB9284467
  • 分子式:C183H288N54O50S2
  • 分子量:4108.71
  • MOL File:Mol file
牛甲状旁腺激活素-(1-34)化学性质
  • 储存条件 :−20°C
  • 溶解度 :≥410.9 mg/mL in DMSO; ≥43.8 mg/mL in H2O; ≥64.6 mg/mL in EtOH
  • 形态 :powder
  • 颜色 :White to off-white
安全信息
  • WGK Germany :3

牛甲状旁腺激活素-(1-34)性质、用途与生产工艺

  • 生物活性 Parathyroid Hormone (1-34), bovine 是一种有效的甲状旁腺激素 (PTH) 受体激动剂。Parathyroid Hormone (1-34), bovine 增加钙和无机磷酸盐的水平。Parathyroid Hormone (1-34), bovine 可用于研究骨质疏松症。
  • 体外研究

    Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal.Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group.

    Cell Proliferation Assay

    Cell Line: MC3T3-E1 cells
    Concentration: 0.1-100 ng/mL
    Incubation Time: 2-20 days
    Result: Resulted a decrease of osteoblast proliferationin concentration-dependent manner. Resulted in a rebound of proliferation when PTH withdrawal.
  • 体内研究

    Parathyroid Hormone (1-34)(subcutaneous injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals. Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls.

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牛甲状旁腺激活素-(1-34) 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-P1252
  • 产品名称:Parathyroid Hormone (1-34), bovine
  • CAS编号:
  • 包装:1 mg
  • 价格:1100元
  • 更新日期:2024/11/08
  • 产品编号:HY-P0059
  • 产品名称:牛甲状旁腺激活素-(1-34) Teriparatide
  • CAS编号:12583-68-5
  • 包装:1mg
  • 价格:800元
牛甲状旁腺激活素-(1-34)生产厂家
  • 公司名称:SIGMA
  • 联系电话:--
  • 电子邮件:
  • 国家:瑞士
  • 产品数:6896
  • 优势度:91
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