牛甲状旁腺激活素-(1-34)
- CAS号:12583-68-5
- 英文名:PARATHYROID HORMONE (1-34), BOVINE
- 中文名:牛甲状旁腺激活素-(1-34)
- CBNumber:CB9284467
- 分子式:C183H288N54O50S2
- 分子量:4108.71
- MOL File:Mol file
- 储存条件 :−20°C
- 溶解度 :≥410.9 mg/mL in DMSO; ≥43.8 mg/mL in H2O; ≥64.6 mg/mL in EtOH
- 形态 :powder
- 颜色 :White to off-white
- WGK Germany :3
牛甲状旁腺激活素-(1-34)性质、用途与生产工艺
- 生物活性 Parathyroid Hormone (1-34), bovine 是一种有效的甲状旁腺激素 (PTH) 受体激动剂。Parathyroid Hormone (1-34), bovine 增加钙和无机磷酸盐的水平。Parathyroid Hormone (1-34), bovine 可用于研究骨质疏松症。
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体外研究
Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal.Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group.
Cell Proliferation Assay
Cell Line: MC3T3-E1 cells Concentration: 0.1-100 ng/mL Incubation Time: 2-20 days Result: Resulted a decrease of osteoblast proliferationin concentration-dependent manner. Resulted in a rebound of proliferation when PTH withdrawal. -
体内研究
Parathyroid Hormone (1-34)(subcutaneous injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals. Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls.
- 更新日期:2024/11/08
- 产品编号:HY-P1252
- 产品名称:Parathyroid Hormone (1-34), bovine
- CAS编号:
- 包装:1 mg
- 价格:1100元
- 更新日期:2024/11/08
- 产品编号:HY-P0059
- 产品名称:牛甲状旁腺激活素-(1-34) Teriparatide
- CAS编号:12583-68-5
- 包装:1mg
- 价格:800元
- 公司名称:SIGMA
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- 国家:瑞士
- 产品数:6896
- 优势度:91
- PTH (1-31) (HUMAN) PTH (1-84) (RAT) SER-VAL-SER-GLU-ILE-GLN-LEU-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-VAL-ALA-LEU-GLY 甲状旁腺素(鼠) PTH (1-34) (PORCINE) 甲状旁腺素 pTH (1-84) (dog) PTH (1-34) AMIDE (HUMAN) ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE: AVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNF PARATHYROID HORMONE (1-37), HUMAN GLU-ALA-ASP-LYS-ALA-ASP-VAL-ASN-VAL-LEU-THR-LYS-ALA-LYS-SER-GLN ALA-PRO-LEU-ALA-PRO-ARG-ASP-ALA-GLY-SER-GLN-ARG-PRO-ARG-LYS-LYS-GLU-ASP-ASN-VAL-LEU-VAL-GLU-SER-HIS-GLU-LYS-SER-LEU-GLY-GLU-ALA-ASP-LYS-ALA-ASP-VAL-ASN-VAL-LEU-THR-LYS-ALA-LYS-SER-GLN ALA-PRO-LEU-ALA-PRO-ARG-ASP-ALA-GLY-SER-GLN-ARG-PRO-ARG-LYS-LYS-GLU-ASP-ASN-VAL-LEU-VAL-GLU-SER-HIS-GLU-LYS-SER-LEU-GLY 异氰酸叔丁酯 乙酰丙酮铬盐 对甲基苯磺酰甲基异腈 三乙酰丙酮铁 三(2,2,6,6-四甲基-3,5-庚二酸)铕