FATOSTATIN A

生物活性靶点体外研究体内研究 FATOSTATIN A 试剂级价格

FATOSTATIN A

CAS号:125256-00-0
英文名:Fatostatin A
中文名:FATOSTATIN A
CBNumber:CB92627880
分子式:C18H18N2S
分子量:294.41
MOL File:125256-00-0.mol

FATOSTATIN A化学性质

沸点 :474.3±55.0 °C(Predicted)
密度 :1.125±0.06 g/cm3(Predicted)
储存条件 :under inert gas (nitrogen or Argon) at 2-8°C
溶解度 :Soluble in DMSO (up to 25 mg/ml).
形态 :solid
酸度系数(pKa) :3.46±0.10(Predicted)
颜色 :Yellow
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

FATOSTATIN A性质、用途与生产工艺

生物活性 Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。
靶点
Target Value
SREBP
()

体外研究

Fatostatin (125B11) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC ₅₀ =0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin inhibits insulin-induced adipogenesis of 3T3-L1 cells.
Fatostatin directly binds SCAP and blocks its ER-to-Golgi transport with IC ₅₀ of 2.5 and 10 μM in mammalian cells.

Cell Proliferation Assay

Cell Line:	DU-145 cells
Concentration:	0.1, 1 μM
Incubation Time:	3 days
Result:	Impaired the IGF1-induced growth at an IC ₅₀ of 0.1 μM.

体内研究

Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in ob/ob mice.

Animal Model:	Four-to-five-week-old homozygous male obese ( ob/ob ) mice (C57BL/6J)
Dosage:	30 mg/kg; 150 μL
Administration:	i.p. injection; daily for 28 days
Result:	Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.