ChemicalBook CAS数据库列表 PD 123319 二(三氟乙酸盐)
PD 123319 二(三氟乙酸盐)
- CAS号:136676-91-0
- 英文名:S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt
- 中文名:PD 123319 二(三氟乙酸盐)
- CBNumber:CB92100002
- 分子式:C33H33F3N4O5
- 分子量:622.65
- MOL File:136676-91-0.mol
PD 123319 二(三氟乙酸盐)化学性质
- 储存条件 :2-8°C
- 溶解度 :H2O: soluble10mg/mL, clear
- 形态 :powder
- 颜色 :White to yellow
- 水溶解性 :Soluble to 100 mM in water
安全信息
PD 123319 二(三氟乙酸盐)性质、用途与生产工艺
- 生物活性 PD 123319 ditrifluoroacetate 是一种有效的，选择性的 AT2 angiotensin II receptor 拮抗剂，IC50 值为 34 nM。
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靶点
IC50: 34 nM (AT2 Receptor)
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体外研究
PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125 I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC 50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125 I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC 50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC 50 around 10 microM).
PD 123319 二(三氟乙酸盐)上下游产品信息
上游原料
下游产品
PD 123319 二(三氟乙酸盐)生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
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