PD 123319 二(三氟乙酸盐)

IC50: 34 nM (AT2 Receptor)

PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. ¹²⁵ I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC ₅₀ of 92.9 nM) for DuP-753. PD-123319 does not have any effect on ¹²⁵ I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC ₅₀ of 6.9 nM, and has a much lower affinity for DuP-753 (IC ₅₀ around 10 microM).