SIRT1/2 INHIBITOR IV
- CAS号:14513-15-6
- 英文名:NSC-1125476, Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-Pyrimidinone, 5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidinone
- 中文名:SIRT1/2 INHIBITOR IV
- CBNumber:CB92099412
- 分子式:C21H16N2O2S
- 分子量:360.43
- MOL File:14513-15-6.mol
- 熔点 :235 °C(dec.)
- 密度 :1.41±0.1 g/cm3(Predicted)
- 储存条件 :room temp
- 溶解度 :DMSO: ≥10mg/mL
- 形态 :White solid
- 酸度系数(pKa) :7.24±0.25(Predicted)
- 颜色 :White to Off-White
SIRT1/2 INHIBITOR IV性质、用途与生产工艺
- 生物活性 Cambinol是一种新型的、非竞争性的nSMase2抑制剂，Ki值为7 μM。
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靶点
Target Value nSMase2
(Cell-free assay)7 μM(Ki) -
体外研究
Cambinol inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2. Inhibition of SIRT1 activity with cambinol during genotoxic stress leads to hyperacetylation of key stress response proteins and promotes cell cycle arrest. Treatment of BCL6-expressing Burkitt lymphoma cells with cambinol as a single agent induces apoptosis, which is accompanied by hyperacetylation of BCL6 and p53. Cambinol has only weak inhibitory activity against SIRT5 (42% inhibition at 300 μM) and no activity against SIRT3.
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体内研究
Cambinol is well tolerated in mice (100 mg/kg) and inhibits growth of Burkitt lymphoma xenografts. No significant weight loss occurs in cambinol-treated animals relative to controls. Inhibitors of NAD-dependent deacetylases may constitute novel anticancer agents.
- 更新日期：2024/11/08
- 产品编号：HY-100732
- 产品名称：SIRT1/2 INHIBITOR IV Cambinol
- CAS编号：14513-15-6
- 包装：5mg
- 价格：990元
- 更新日期：2024/11/08
- 产品编号：HY-100732
- 产品名称：SIRT1/2 INHIBITOR IV Cambinol
- CAS编号：14513-15-6
- 包装：10mM * 1mLin DMSO
- 价格：1089元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
