SAG
- CAS号:912545-86-9
- 英文名:SAG
- 中文名:SAG
- CBNumber:CB91565561
- 分子式:C28H28ClN3OS
- 分子量:490.06
- MOL File:912545-86-9.mol
- 沸点 :688.6±55.0 °C(Predicted)
- 密度 :1.30±0.1 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
- 酸度系数(pKa) :10?+-.0.40(Predicted)
- 形态 :lyophilized solid
- 颜色 :white to beige
- 敏感性 :Light Sensitive
- 稳定性 :Light Sensitive
- 危险品运输编号 :UN 2811 6.1 / PGIII
- 海关编码 :2934999090
SAG性质、用途与生产工艺
- 生物活性 SAG 是一种有效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)。SAG 可激活 Hedgehog 信号通路并抵消 Cyclopamine (HY-17024) 对 Smo 的抑制作用。
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靶点
EC50: 3 nM (Smo)
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体外研究
SAG (0.1 nM-100 μM; 30 h) induces firefly luciferase expression in Shh-LIGHT2 cells with an EC 50 of 3 nM and then inhibits expression at higher concentrations.
SAG (1-1000 nM; 1 h) competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, yielding an apparent dissociation constant (K d ) of 59 nM for the SAG/Smo complex.
SAG (100 nM) inhibits the inhibitory effect of ShhN-induced pathway activation by Robotnikinin.
SAG (250 nM; 48 h) significantly increases SMO mRNA and protein expression in MDAMB231 cells.
SAG (250 nM; 24 and 48 h) increases CAXII mRNA expression in MDAMB231 cells at 24h in normoxic and hypoxic conditions in MDAMB231 cells.
SAG (250 nM; 24 h) increases MDAMB231 cells migration. -
体内研究
SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight week timepoint in CD-1 mice.
SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice.Animal Model: Pregnant C57BL/6J mice Dosage: 15, 17, 20 mg/kg Administration: A single i.p. Result: Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg.
- 更新日期：2024/11/08
- 产品编号：HY-12848
- 产品名称：SAG SAG
- CAS编号：912545-86-9
- 包装：1mg
- 价格：600元
- 更新日期：2024/11/08
- 产品编号：HY-12848
- 产品名称：SAG SAG
- CAS编号：912545-86-9
- 包装：5mg
- 价格：1800元
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
- 公司名称：CMS-CHEMICAL
- 联系电话：--
- 电子邮件：cms.marketing@cms-chemicals.com
- 国家：英国
- 产品数：3708
- 优势度：60
