Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂

生物活性靶点体外研究 Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂试剂级价格

CAS号:74389-68-7
英文名:Platelet Activating Factor-16
中文名:Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂
CBNumber:CB9143348
分子式:C26H54NO7P
分子量:523.68
MOL File:74389-68-7.mol

Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂化学性质

熔点 :247 °C
储存条件 :-20°C
溶解度 :Soluble in H2O or ethanol
形态 :lyophilized powder
颜色 :White to off-white
水溶解性 :Soluble to 100 mM in water
BRN :3574588

安全信息

危险品标志 :Xn
危险类别码 :22-38-40-48/20/22
安全说明 :36/37-24/25-22
危险品运输编号 :UN 1888 6.1/PG 3
WGK Germany :3
RTECS号 :EC6060000
F :10-21

Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂性质、用途与生产工艺

生物活性 C16-PAF (PAF (C16)) 是一种磷脂介质，是血小板活化因子，也是 PAF G 蛋白偶联受体 (PAFR) 的配体。C16-PAF 表现出抗凋亡作用，并通过激活 PAFR 来抑制 caspase 依赖性死亡。C16-PAF 是有效的 MAPK 和 MEK/ERK 激活剂。C16-PAF 诱导血管通透性增加。
靶点

Human Endogenous Metabolite

ERK

MEK

体外研究

C16-PAF (PAF (C16); 0.5-1.5 μM; for 24 hours) elicits significant concentration-dependent neuronal loss in PAFR ^−/− but not PAFR ^+/+ cultures. C16-PAF (1 μM) elicits neuronal death in PAFR ^−/− cells infected with EGFP alone.
C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3 in PAFR ^−/− neurons.
C16-PAF is synthesized by two distinct pathways; the remodeling pathway and the de novo synthesis pathway. C16-PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor.
C16-PAF (1-25 μg/ml; 6, 12, 24 h) inhibits M. smegmatis and M. bovis BCG growth in a time-dependent manner.

Cell Viability Assay

Cell Line:	Cerebellar granule neurons (CGNs) from PAFR ^−/− and PAFR ^+/+ mice
Concentration:	0.5-1.5 μM
Incubation Time:	24 hours
Result:	Elicited significant concentration-dependent neuronal loss in PAFR ^−/− but not PAFR ^+/+ cultures in serum-free media.