L-高胱氨酸硫内酯盐酸盐
- CAS号:31828-68-9
- 英文名:L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
- 中文名:L-高胱氨酸硫内酯盐酸盐
- CBNumber:CB9137747
- 分子式:C4H8ClNOS
- 分子量:153.63
- MOL File:31828-68-9.mol
- 熔点 :185-191 °C
- 储存条件 :Keep in dark place,Inert atmosphere,Room temperature
- 溶解度 :Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)
- 形态 :Solid
- 颜色 :Pale Beige
- BRN :3911455
- 稳定性 :Hygroscopic
L-高胱氨酸硫内酯盐酸盐性质、用途与生产工艺
- 生物活性 L-Homocysteine thiolactone hydrochloride是同型半胱氨酸的分子内硫酯; 防止同型半胱氨酸转化成蛋白质。
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体外研究
In all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase. Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans. Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester. This conversion occurs in all human cell types, including endothelial cells. Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-3 activation and DNA fragmentation. HcyT strongly activates IL-8 release.
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体内研究
Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer’s disease. Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent.
- 更新日期:2024/11/08
- 产品编号:HY-101404A
- 产品名称:L-高胱氨酸硫内酯盐酸盐 L-Homocysteine thiolactone hydrochloride
- CAS编号:31828-68-9
- 包装:10mg
- 价格:240元
- 更新日期:2024/11/08
- 产品编号:HY-101404A
- 产品名称:L-高胱氨酸硫内酯盐酸盐 L-Homocysteine thiolactone hydrochloride
- CAS编号:31828-68-9
- 包装:10mM * 1mLin Water
- 价格:264元
- 公司名称:SIGMA
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- 国家:瑞士
- 产品数:6896
- 优势度:91