MS-444
- CAS号:150045-18-4
- 英文名:5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone
- 中文名:MS-444
- CBNumber:CB91339067
- 分子式:C13H10O4
- 分子量:230.22
- MOL File:150045-18-4.mol
- 沸点 :448.7±45.0 °C(Predicted)
- 密度 :1.452±0.06 g/cm3(Predicted)
- 酸度系数(pKa) :8.14±0.20(Predicted)
- 形态 :Solid
- 颜色 :Light yellow to brown
MS-444性质、用途与生产工艺
- 生物活性 MS-444 是平滑肌肌球蛋白轻链激酶 (MLCK) 的抑制剂,IC50 值为 10 μM。
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靶点
IC50: 10 μM (myosin).
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体外研究
MS-444 is a small molecule RNA-binding protein HuR (ELAVL1) inhibitor. Colorectal cancer (CRC) cells that display HuR overexpression are treated with MS-444 (1-100 μM) for 48 hr with IC 50 s of 10.98±1.76 μM, 12.84±2.10 μM, 5.60±0.90 μM, 14.21±2.11 μM, and 10.98±1.24 μM for HCT116, HCA-7, RKO, HT-29, and SW480 cells, respectively. Growth inhibition is observed in all CRC lines with IC 50 values ranging from 5.60 μM to 14.21 μM with observable effects seen at 10 μM MS-444. Contrasting effects are observed using non-transformed small intestinal (RIE-1 (IC 50 =40.70±3.53 μM)) and colonic (YAMC (IC 50 =28.16±3.23 μM)) epithelial cells. Both cell types display properties of normal intestinal epithelial cells and are proficient in 3′UTR AU-rich elements (ARE)-mRNA decay. Both non-transformed cell lines are ~3- to 4-fold less responsive to MS-444-mediated growth inhibition, with IC 50 values of 40.70 μM and 28.16 μM ( P <0.05).
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体内研究
To test the effects of MS-444 on CRC cell growth in vivo, mice bearing HCT116 cell xenografts receive IP injections of MS-444 (25 mg/kg bw) or vehicle every 48 hr. Over the experiment course, mice do not display any adverse effects and maintained similar weights. Anti-tumor effects of MS-444 are observed with approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 show a marked 2- to 3-fold decrease in microvessel density (MVD), indicating the anti-angiogenic potential of MS-444.
- 更新日期:2024/04/30
- 产品编号:HY-100685
- 产品名称:MS-444 MS-444
- CAS编号:150045-18-4
- 包装:5mg
- 价格:7500元
- 更新日期:2024/04/30
- 产品编号:HY-100685
- 产品名称:MS-444 MS-444
- CAS编号:150045-18-4
- 包装:10mM * 1mLin DMSO
- 价格:7600元
- 公司名称:BOC Sciences
- 联系电话:1-631-485-4226; 16314854226
- 电子邮件:info@bocsci.com
- 国家:美国
- 产品数:14059
- 优势度:65
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:Aladdin Scientific
- 联系电话:+1-+1(833)-552-7181
- 电子邮件:sales@aladdinsci.com
- 国家:美国
- 产品数:52927
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58