(2,2-二甲基-1-氧代丙氧基)丁酸甲酯
- CAS号:122110-53-6
- 英文名:pivalyloxymethyl butyrate
- 中文名:(2,2-二甲基-1-氧代丙氧基)丁酸甲酯
- CBNumber:CB91321048
- 分子式:C10H18O4
- 分子量:202.25
- MOL File:122110-53-6.mol
- 沸点 :249.3±13.0 °C(Predicted)
- 密度 :1.008±0.06 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :DMSO: ≥10mg/mL
- 形态 :oil
- 颜色 :colorless or slightly yellow
- WGK Germany :nwg
(2,2-二甲基-1-氧代丙氧基)丁酸甲酯性质、用途与生产工艺
- 生物活性 Pivanex (AN-9) 是丁酸的衍生物，是口服有效的 HDAC 抑制剂。Pivanex 可下调 bcr-abl 蛋白，增强凋亡 (apoptosis)。Pivanex 具有抗转移和抗血管生成的活性
-
靶点
HDAC
Bcr-Abl
-
体外研究
Pivanex (100-500 μM) exhibits significant anti-proliferation activity in K562 cells.
Pivanex (100-500 μM) also enhances apoptosis and caspase activity in K562 cells.
Pivanex (200 μM) induces enhancement in the G2-M phase, a moderate enhancement in the S phase and a slight reduction in G0-G1 of the cell cycle.
Pivanex (AN-9) has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines.Cell Viability Assay
Cell Line: K562 cells. Concentration: 100-500 μM. Incubation Time: 24 hours. Result: Reduced the number of K562 viable cells significantly.
100 μM Pivanex with 0.125 or 0.25 μM STI571 reduced the number of viable cells synergistically.Apoptosis Analysis
Cell Line: K562 cells. Concentration: 100-500 μM. Incubation Time: 6-72 hours. Result: Increased the number of K562 apoptotic cells significantly.
Increased the caspase activity in K562 cells significantly after only 4 h of incubation with 500 μM. -
体内研究
Pivanex (AN9, 200 mg/kg, b.i.d, daily) significantly improves the survival of SMN7 SMA mice. Pivanex (AN9) treatment also marked delays the end stage of disease as defined by the onset of body mass loss.
Animal Model: SMN7 SMA mice (SMN2 +/+ ; SMN7 +/+ ; mSmn −/− ). Dosage: 200 mg/kg. Administration: Oral administration, b.i.d, at 09.00 and 17.00 daily. Result: Improved the mean lifespan of treated SMN7 SMA mice by 84.6%.
Delayed the onset of body mass loss in SMN7 SMA mice by 94.9%.
- 更新日期：2024/11/08
- 产品编号：HY-120508
- 产品名称：(2,2-二甲基-1-氧代丙氧基)丁酸甲酯 Pivanex
- CAS编号：
- 包装：10 mg
- 价格：120元
- 更新日期：2024/11/08
- 产品编号：HY-120508
- 产品名称：(2,2-二甲基-1-氧代丙氧基)丁酸甲酯 Pivanex
- CAS编号：
- 包装：25 mg
- 价格：245元
- 公司名称：AmXpress
- 联系电话：--
- 电子邮件：cyu@amxpress.com
- 国家：加拿大
- 产品数：815
- 优势度：51
