ChemicalBook CAS数据库列表 派利文碱
派利文碱
- CAS号:2673-40-7
- 英文名:Vobassan-17-oic acid, 4-demethyl-3-oxo-, methyl ester
- 中文名:派利文碱
- CBNumber:CB91253284
- 分子式:C20H22N2O3
- 分子量:338.4
- MOL File:2673-40-7.mol
派利文碱化学性质
- 熔点 :180-181℃
- 比旋光度 :D26 -121.4° (chloroform)
- 沸点 :541.1±50.0 °C(Predicted)
- 密度 :1.273
- 酸度系数(pKa) :pKa in 66% DMF: 7.5(at 25℃)
派利文碱性质、用途与生产工艺
- 生物活性 Perivine (Perivin) 以视网膜母细胞瘤相关蛋白 (RbAp48) 为靶点，用于解决 RbAp48-FOG-1 复合物的不稳定性。Perivine 可用于阿尔茨海默病的研究。
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靶点
IC50: Retinoblastoma-associated proteins (RbAp48)
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体外研究
Retinoblastoma-associated proteins (RbAp48) are related to Alzheimer's disease (AD), RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription. However, this is an unstable complex may affect the function of RbAp48. Perivine has a greater stable affinity for RbAp48 binding than FOG1, it might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy.
派利文碱上下游产品信息
上游原料
下游产品
派利文碱生产厂家
- 公司名称：CFMOT-PHYTO
- 联系电话：--
- 电子邮件：
- 国家：德国
- 产品数：1136
- 优势度：62
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