ChemicalBook CAS数据库列表 (4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID
生物活性 靶点 体外研究 体内研究
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID 试剂级价格
- CAS号:872993-05-0
- 英文名:(4Z,7S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
- 中文名:(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID
- CBNumber:CB91236229
- 分子式:C22H32O5
- 分子量:376.49
- MOL File:872993-05-0.mol
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID化学性质
- 储存条件 :Store at -80°C,protect from light
- 溶解度 :DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml
- 形态 :Liquid
- 颜色 :Colorless to light yellow
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID性质、用途与生产工艺
- 生物活性 Resolvin D1 (RvD1) 是炎症的一种内源性促分解介质，衍生自在急性炎症的缓解阶段的 omega-3二十二碳六烯酸。Resolvin D1 通过调节肌动蛋白聚合来阻止促炎性中性粒细胞迁移，减少巨噬细胞中 TNF-α 介导的炎症，并增强巨噬细胞对凋亡细胞的吞噬作用。
-
靶点
Human Endogenous Metabolite
-
体外研究
Resolvin D1 (RvD1) (1-100 nM; 15 minutes) induces dose-dependent short-term functional changes in primary human macrophages. RvD1 triggers intracellular Ca 2+ release, blocks chemotactic migration, and stimulates phagocytosis of microbial particles with maximal efficiency at 10 nM. Resolvin D1 (0-500 nM; 72 hours) shows a strong inhibition of LPS-induced TRAP and cathepsin K expression by RvD1 at different concentrations in RAW264.7 macrophages.
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体内研究
Resolvin D1 (RvD1) (100-1000 ng; i.p.; daily on days 10) improves RA (rheumatoid arthritis) clinical endpoints in arthritic mice.
Animal Model: 18-20 g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA)) Dosage: 100, 500, and 1000 ng (or 1000 ng, daily on days 4-10) Administration: i.p. injection; daily on days 10 Result: Exhibit a reduced arthritic score.
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID上下游产品信息
上游原料
下游产品
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-125527
- 产品名称：(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID Resolvin D1
- CAS编号：872993-05-0
- 包装：25μg(265.6μM * 250μL in Ethanol)
- 价格：8500元
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
872993-05-0, (4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID相关搜索:
