ChemicalBook CAS数据库列表 净特罗
净特罗
- CAS号:37000-20-7
- 英文名:N-(2-HYDROXY-5-(1-HYDROXY-2-(2-METHYL-1-PHENYLPROPAN-2-YLAMINO)ETHYL)PHENYL)METHANE
- 中文名:净特罗
- CBNumber:CB91119179
- 分子式:C19H26N2O4S
- 分子量:378.49
- MOL File:37000-20-7.mol
净特罗化学性质
- 沸点 :574.3±60.0 °C(Predicted)
- 密度 :1.282±0.06 g/cm3(Predicted)
- 储存条件 :Store at +4°C
- 溶解度 :Soluble to 5 mM in water and to 100 mM in DMSO
- 形态 :Powder
- 酸度系数(pKa) :8.57±0.50(Predicted)
- 颜色 :White to off-white
净特罗性质、用途与生产工艺
- 生物活性 Zinterol (MJ 9184) 是一种有效的选择性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂。Zinterol 增强 ICa，EC50 为 2.2 nM。
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靶点
β2-adrenoceptor
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体内研究
Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits.
Animal Model: In New Zealand White HF rabbits of either sex Dosage: 1.0 or 2.5 μg/kg Administration: Intravenous bolus administration; over 5 seconds Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.
净特罗上下游产品信息
上游原料
下游产品
净特罗 试剂级价格
- 更新日期：2023/03/20
- 产品编号：HY-14304
- 产品名称：净特罗 Zinterol
- CAS编号：37000-20-7
- 包装：1mg
- 价格：1550元
- 更新日期：2023/03/20
- 产品编号：HY-14304
- 产品名称：净特罗 Zinterol
- CAS编号：37000-20-7
- 包装：10mM * 1mLin DMSO
- 价格：3872元
净特罗生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
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