NCH-51
- CAS号:848354-66-5
- 英文名:PTACH
- 中文名:NCH-51
- CBNumber:CB8972794
- 分子式:C20H26N2O2S2
- 分子量:390.56
- MOL File:848354-66-5.mol
- 熔点 :127-128 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
- 密度 :1.181±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble26mg/mL
- 形态 :White powder
- 酸度系数(pKa) :9.52±0.50(Predicted)
- 颜色 :White to off-white
NCH-51性质、用途与生产工艺
- 生物活性 PTACH (NCH-51) 是一种有效的 HDAC 抑制剂，对 HDAC1，HDAC4 和 HDAC6 的 IC50 分别为 48 nM，32 nM 和 41 nM。PTACH 对多种癌细胞具有强大的生长抑制作用 (EC50 为 1.1-9.1 µM)。
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靶点
HDAC1
48 nM (IC 50 )
HDAC4
32 nM (IC 50 )
HDAC6
41 nM (IC 50 )
HIV-1
-
体外研究
PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21 WAF1/CIP1 in a dose-dependent manner.
In cancer cell growth inhibition assay, PTACH (compound 51) shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μM, 9.1 μM, 3.0 μM, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively.
PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter.Western Blot Analysis
Cell Line: HCT 116 cells Concentration: 1 μM, 5 μM, 25 μM Incubation Time: 8 hours Result: Gave rise to elevated and dose-dependent levels of acetylated histone H4 and p21 WAF1/CIP1 .
- 公司名称：SIGMA
- 联系电话：--
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- 国家：瑞士
- 产品数：6896
- 优势度：91
