2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
- CAS号:68003-38-3
- 英文名:2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
- 中文名:2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
- CBNumber:CB8884338
- 分子式:C13H9ClN2O6S
- 分子量:356.74
- MOL File:68003-38-3.mol
- 沸点 :564.8±60.0 °C(Predicted)
- 密度 :1.660±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO:125 mg/mL(350.40 mM)
- 形态 :A solid
- 酸度系数(pKa) :3.19±0.36(Predicted)
- 颜色 :Off-white to light yellow
- EPA化学物质信息 :Benzoic acid, 2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]- (68003-38-3)
2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸性质、用途与生产工艺
- 生物活性 CTPI-2 是一种线粒体柠檬酸盐载体 SLC25A1 的抑制剂，KD值为3.5 μM。CTPI-2 是 glycolysis 的独特调节剂，它限制了癌症干细胞(CSCs)的代谢可塑性。
-
靶点
Target Value glycolysis
()SLC25A1
(Cell-free assay)3.5 μM(Kd) -
体内研究
CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). CTPI-2 (26 mg/kg; i.p.) inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC).
CTPI-2 (50 mg/kg; i.p.; alternate days for 12 weeks) completely averts weight gain in the prevention study and leads to significant weight loss in the reversion study.
CTPI-2 prevents steatohepatitis and normalizes glucose tolerance. CTPI-2 lowers the levels of circulating IL-6 while increasing anti-inflammatory IL-4 and IL-10 and also reduced the monocyte chemoattractant protein-1 and monokine-induced by interferon-γ that attract neutrophils and monocytes. CTPI-2 regulates the citrate pool, the lipogenic and the gluconeogenic pathways.Animal Model: C57BL/6J mice (HFD-fed mice) Dosage: 50 mg/kg Administration: Alternate days via the intraperitoneal route for 12 weeks Result: Completely averted weight gain in the prevention study and led to significant weight loss in the reversion study.
- 更新日期：2024/11/08
- 产品编号：S2968
- 产品名称：2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸 CTPI-2
- CAS编号：68003-38-3
- 包装：5mg
- 价格：1384.11元
- 更新日期：2024/11/08
- 产品编号：S2968
- 产品名称：CTPI-2
- CAS编号：68003-38-3
- 包装：10mM (1mL in DMSO)
- 价格：1613.43元
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
