2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸

生物活性靶点体内研究 2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸试剂级价格

CAS号:68003-38-3
英文名:2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
中文名:2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
CBNumber:CB8884338
分子式:C13H9ClN2O6S
分子量:356.74
MOL File:68003-38-3.mol

2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸化学性质

沸点 :564.8±60.0 °C(Predicted)
密度 :1.660±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMSO:125 mg/mL(350.40 mM)
形态 :A solid
酸度系数(pKa) :3.19±0.36(Predicted)
颜色 :Off-white to light yellow
EPA化学物质信息 :Benzoic acid, 2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]- (68003-38-3)

2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸性质、用途与生产工艺

生物活性 CTPI-2 是一种线粒体柠檬酸盐载体 SLC25A1 的抑制剂，KD值为3.5 μM。CTPI-2 是 glycolysis 的独特调节剂，它限制了癌症干细胞(CSCs)的代谢可塑性。
靶点
Target Value
glycolysis
()
SLC25A1
(Cell-free assay) 3.5 μM(Kd)

体内研究

CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). CTPI-2 (26 mg/kg; i.p.) inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC).
CTPI-2 (50 mg/kg; i.p.; alternate days for 12 weeks) completely averts weight gain in the prevention study and leads to significant weight loss in the reversion study.
CTPI-2 prevents steatohepatitis and normalizes glucose tolerance. CTPI-2 lowers the levels of circulating IL-6 while increasing anti-inflammatory IL-4 and IL-10 and also reduced the monocyte chemoattractant protein-1 and monokine-induced by interferon-γ that attract neutrophils and monocytes. CTPI-2 regulates the citrate pool, the lipogenic and the gluconeogenic pathways.

Animal Model:	C57BL/6J mice (HFD-fed mice)
Dosage:	50 mg/kg
Administration:	Alternate days via the intraperitoneal route for 12 weeks
Result:	Completely averted weight gain in the prevention study and led to significant weight loss in the reversion study.