3-脱氮腺苷
- CAS号:6736-58-9
- 英文名:3-DEAZAADENOSINE
- 中文名:3-脱氮腺苷
- CBNumber:CB8680473
- 分子式:C11H14N4O4
- 分子量:266.25
- MOL File:6736-58-9.mol
- 熔点 :228-229°C
- 沸点 :665.7±65.0 °C(Predicted)
- 密度 :1.90±0.1 g/cm3 (20 ºC 760 Torr)
- 储存条件 :Keep in dark place,Inert atmosphere,2-8°C
- 溶解度 :H2O: 10 mg/mL with heating to 60 °C
- 形态 :Solid
- 酸度系数(pKa) :13.24±0.70(Predicted)
- 颜色 :White to Off-White
- 安全说明 :24/25
- 危险品运输编号 :2811
- WGK Germany :3
- 危险等级 :6.1(a)
- 包装类别 :II
- 海关编码 :29419090
3-脱氮腺苷性质、用途与生产工艺
- 生物活性 3-Deazaadenosine 是一种 S-腺苷高半胱氨酸水解酶 (S-adenosylhomocysteine hydrolase) 抑制剂,Ki 值为 3.9 µM;3-Deazaadenosine 具有抗炎、抗增殖、抗 HIV 等活性。
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靶点
IC50: 0.15 (HIV-1, A012 isolate), 0.20 µM (HIV-1, A018 isolate)
Ki: 3.9 µM (S-adenosylhomocysteine hydrolase) -
体外研究
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 µM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 µM, respectively. 3-Deazaadenosine (1-100 µM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 µM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 µM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 µM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.
- 更新日期:2024/04/30
- 产品编号:HY-W013332
- 产品名称:3-Deazaadenosine
- CAS编号:
- 包装:1 mg
- 价格:1800元
- 更新日期:2024/04/30
- 产品编号:HY-W013332
- 产品名称:3-Deazaadenosine
- CAS编号:
- 包装:5 mg
- 价格:3900元
- 公司名称:SIGMA
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- 国家:瑞士
- 产品数:6913
- 优势度:91