ChemicalBook CAS数据库列表 579492-81-2
579492-81-2
- CAS号:579492-81-2
- 英文名:BAX INHIBITING PEPTIDE V5 (BIP-V5)
- 中文名:579492-81-2
- CBNumber:CB8503178
- 分子式:C27H50N6O6S
- 分子量:586.79
- MOL File:579492-81-2.mol
579492-81-2化学性质
- 沸点 :907.2±65.0 °C(Predicted)
- 密度 :1.185±0.06 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :≥29.35 mg/mL in DMSO; insoluble in EtOH; ≥91.4 mg/mL in H2O
- 形态 :lyophilized powder
- 酸度系数(pKa) :3.31±0.10(Predicted)
- 颜色 :White to off-white
安全信息
- WGK Germany :3
579492-81-2性质、用途与生产工艺
- 生物活性 Bax inhibitor peptide V5 (BIP-V5) 是一种 Bax 诱导凋亡的抑制剂，主要用于癌症研究。
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靶点
Bax
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体外研究
Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively.
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体内研究
Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model.
579492-81-2上下游产品信息
上游原料
下游产品
579492-81-2生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
