TM-25659
- CAS号:260553-97-7
- 英文名:TM-25659
- 中文名:TM-25659
- CBNumber:CB84845065
- 分子式:C30H28N8
- 分子量:500.6
- MOL File:260553-97-7.mol
- 沸点 :768.0±70.0 °C(Predicted)
- 密度 :1.29±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : ≥ 135 mg/mL (269.68 mM);Water : < 0.1 mg/mL (insoluble)
- 形态 :Solid
- 酸度系数(pKa) :4.15±0.10(Predicted)
- 颜色 :White to off-white
TM-25659性质、用途与生产工艺
- 生物活性 TM-25659是 具有PDZ结合基序的转录共激活子 (TAZ) 的调制剂。抗骨质疏松和抗肥胖活性。
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靶点
TAZ
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体外研究
TM-25659 (2, 10, 20, 100 μM) enhances nuclear TAZ localization in a dose-dependent manner and attenuates PPARγ-mediated adipocyte differentiation by facilitating PPARγ suppression activity of TAZ.
TM-25659 (2, 10, 50 μM) enhances osteogenic gene expression and thereby increases osteoblast differentiation.
Cell Proliferation Assay
Cell Line: 3T3-L1 cells Concentration: 2, 10, 20, 100 μM Incubation Time: 6 days Result: Acted as a suppressor of PPARγ-dependent adipocyte differentiation [1] . -
体内研究
TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss in vivo and decreases weight gain in an obesity model.
TM-25659 has a favourable pharmacokinetic profile in rats. The plasma concentration of TM-25659 declines with an approximate t 1/2 of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 L×h -1 ×kg -1 and the volume of distribution at steady-state (1.91 L×h -1 ×kg -1 ) is larger than the volume of total body fluids.
Animal Model: C57BL6 mice (4- to 6-week-old ) Dosage: 50 mg/kg Administration: I.p., every other day for 2 weeks Result: Attenuated weight gain in these obese mice [1] . Animal Model: Adult male Sprague-Dawley rats Dosage: 10 mg/kg Administration: I.v. (2, 10 and 30 min), oral (15 and 30 min, and 1, 2, 4 and 8 h) Result: Oral administration for 4 weeks moderately but significantly attenuated weight gain and partly restored BMD in the OVX rats [1] .
- 更新日期：2024/11/08
- 产品编号：HY-112920
- 产品名称：TM-25659 TM-25659
- CAS编号：260553-97-7
- 包装：5mg
- 价格：950元
- 更新日期：2024/11/08
- 产品编号：HY-112920
- 产品名称：TM-25659 TM-25659
- CAS编号：260553-97-7
- 包装：10mM * 1mLin DMSO
- 价格：1050元
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
