ChemicalBook CAS数据库列表 ML-00253764 HYDROCHLORIDE
ML-00253764 HYDROCHLORIDE
- CAS号:1706524-94-8
- 英文名:ML-00253764 (hydrochloride)
- 中文名:ML-00253764 HYDROCHLORIDE
- CBNumber:CB84667027
- 分子式:C18H19BrClFN2O
- 分子量:413.72
- MOL File:1706524-94-8.mol
ML-00253764 HYDROCHLORIDE化学性质
- 储存条件 :Store at -20°C
- 溶解度 :DMF: 30mg/mL; DMF:PBS (pH 7.2) (1:20): 0.5mg/mL; DMSO: 25mg/mL; Ethanol: 1mg/mL
- 形态 :A crystalline solid
- 颜色 :Off-white to light yellow
ML-00253764 HYDROCHLORIDE性质、用途与生产工艺
- 生物活性 ML-00253764 是一种非肽类黑皮质素受体4 (MC4R) 拮抗剂，其 Ki 和 IC50 值分别为 0.16 µM 和 0.103 µM。脑渗透剂。
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体外研究
ML-00253764 displaces NDP-α-MSH binding with a mean IC 50 of 0.32 μM, 0.81 μM and 2.12 μM for hMC4-R, hMC3-R and hMC5-R, respectively. ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes.
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体内研究
ML-00253764 (subcutaneous injection; 3, 10, or 30 mg/kg; once daily) shows protection against tumor-induced body weight loss upon chronic, peripheral dosing in CT-26 tumor bearing BALB/c mice.ML-00253764 dissolves in polyethylene glycol 200/saline (1:10) in a volume of 10 ml/kg.
Animal Model: CT-26 tumor bearing BALB/c mice Dosage: 3, 10, or 30 mg/kg Administration: Subcutaneous injection; 3, 10, or 30 mg/kg; once daily Result: Reduced tumor-induced weight loss in a mouse model.
ML-00253764 HYDROCHLORIDE上下游产品信息
上游原料
下游产品
ML-00253764 HYDROCHLORIDE生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
