肾上腺髓质素(22-52 )(人体)

肾上腺髓质素(22-52 )(人体)化学性质

密度 :1.50±0.1 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :Soluble in DMSO
形态 :Solid
颜色 :White to off-white
序列 :H-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

安全信息

肾上腺髓质素(22-52 )(人体)性质、用途与生产工艺

生物活性 Adrenomedullin (AM) (22-52), human，NH2 末端截短的 adrenomedullin 类似物，为肾上腺髓质素 (adrenomedullin receptor) 受体拮抗剂，同时在猫后肢血管床中，对降钙素基因相关肽 (CGRP) 受体也具有拮抗作用。
靶点

Adrenomedullin receptor, CGRP receptor
体外研究

Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist.
Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells.
参考质量标准外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%

肾上腺髓质素(22-52 )(人体)上下游产品信息

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下游产品

肾上腺髓质素(22-52 )(人体)生产厂家

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