甲异靛
- CAS号:97207-47-1
- 英文名:Meisoindigo
- 中文名:甲异靛
- CBNumber:CB8394558
- 分子式:C17H12N2O2
- 分子量:276.29
- MOL File:97207-47-1.mol
- 熔点 :236-237°C
- 沸点 :482.0±45.0 °C(Predicted)
- 密度 :1.381±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic
- 形态 :powder to crystal
- 酸度系数(pKa) :11.62±0.20(Predicted)
- 颜色 :Orange to Brown to Dark red
- 海关编码 :2933.79.1500
甲异靛 化学药品说明书
异甲靛片
甲异靛片
甲异靛性质、用途与生产工艺
- 生物活性 Meisoindigo (Dian III) 是 Indirubin (HY-N0117) 的衍生物，可以造成急性髓细胞性白血病 (AML) 细胞周期在 G0/G1 期停滞，并诱导凋亡。Meisoindigo 具有很高的抗肿瘤活性。
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体外研究
Meisoindigo (Dian III; 5-20 μM; for 24 hours) inhibits growth of the AML cell lines.
Meisoindigo (10 μM; for 24 hours) induces apoptosis of acute myeloid leukemia.
Meisoindigo (5-10 μM; for 24 hours) causes cell-cycle arrest.
Meisoindigo (5-10 μM; for 24 hours) increases the cleaved caspase-3 and pro-apoptotic Bak, and decreases Bcl-2 and Bcl-xL levels in HL-60 cells.
Meisoindigo (10, 30, 50, 100, 150 μM; 24 hours) interdicts LPS-induced (1 μg/mL) NLRP3 inflammasome activation and M1/M2 polarization through down-regulation of TLR4 pathways after OGD/R in HT-22 and BV2 cells.
Cell Viability Assay
Cell Line: HL-60, NB4, U937 leukemic cell lines Concentration: 5, 10, 15, 20 μM Incubation Time: For 24 hours Result: Inhibited growth of the AML cell lines in a dose- and time-dependent manner. Apoptosis Analysis
Cell Line: HL-60 cells Concentration: 10 μM Incubation Time: For 24 hours Result: Induced apoptosis of acute myeloid leukemia. Cell Cycle Analysis
Cell Line: HL-60 cells Concentration: 5, 10 μM Incubation Time: For 24 hours Result: Caused cell-cycle arrest, with more cells in sub-G1 and G0/G1 phases and fewer cells in the S phase, in a dose-dependent manner. Western Blot Analysis
Cell Line: HL-60 cells Concentration: 5, 10 μM Incubation Time: For 24 hours Result: Increased the cleaved caspase-3 and pro-apoptotic Bak, and decreased Bcl-2 and Bcl-xL levels in HL-60 cells. -
体内研究
Meisoindigo (Dian III; 50-150 mg/kg; IP; daily; for 14 days) has anti-leukemic activity in vivo.
Meisoindigo (2, 4, 8, 12 mg/kg; IP; before MCAO and 2 h after reperfusion) significantly reduces infarct volume, ameliorates neurological deficits 3 days after middle cerebral artery occlusion (MCAO) in Wild-type C57BL/6J mice (25-30 g). Meisoindigo reduces edema and lowers AQP4 expression in the brain.
Animal Model: NOD/SCID mice, 6-8 weeks old, with HL-60 leukemic cells Dosage: 50, 100, 150 mg/kg Administration: IP; daily; for 14 days Result: Had anti-leukemic activity in vivo.
- 更新日期：2025/02/05
- 产品编号：HY-13680
- 产品名称：甲异靛 Meisoindigo
- CAS编号：97207-47-1
- 包装：1 mg
- 价格：320元
- 更新日期：2025/02/05
- 产品编号：HY-13680
- 产品名称：甲异靛 Meisoindigo
- CAS编号：97207-47-1
- 包装：5mg
- 价格：800元
- 公司名称：TCI Europe
- 联系电话：320-37350700
- 电子邮件：sales@tcieurope.eu
- 国家：欧洲
- 产品数：23671
- 优势度：75
