ChemicalBook CAS数据库列表 (2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole

(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole

CAS号:1075723-01-1
英文名:(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole
中文名:(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole
CBNumber:CB83889510
分子式:C26H18N2
分子量:358.43
MOL File:1075723-01-1.mol

(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole性质、用途与生产工艺

生物活性 Fulvene-5 是一种有效的 NADPH 氧化酶 4 (NOX4) 抑制剂，具有抗氧化特性。Fulvene-5 是一种活性氧 (ROS) 修饰剂和有效的辐射防护剂，并具有抗肿瘤活性。
靶点

NADPH oxidase 4 (NOX4); Reactive oxygen species (ROS)
体外研究

Fulvene-5 (10 µM; 1 hour) facilitates the reversal of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures adaptive responses from pro-survival to radio-sensitization and vice versa. These changes are accompanied by corresponding reversals in the translocation of survivin to the nuclei of TP53 WT and to the cytoplasm of TP53 Mut cells. The potential role of NOX4 in the expression of the survivin-associated adaptive response is investigated by transfecting HCT116 cells with NOX4 siRNA oligomers to inhibit NOX4 expression. Under these conditions NOX4 expression is inhibited by about 50%.
Fulvene-5 (0.5-1.0 μM) treatment decreases the expression of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in a dose-dependent manner in bEnd.3 cells.

体内研究

Fulvene-5 (120 mg/kg/d; intraperitoneal injection; daily; for 2 weeks; nude mice) treatment potently inhibits hemangioma growth in mice.

Animal Model:	Nude mice injected with bEnd.3 cells
Dosage:	120 mg/kg/d
Administration:	Intraperitoneal injection; daily; for 2 weeks
Result:	Tumor growth in mice was significantly reduced.

(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole上下游产品信息

上游原料

下游产品

更新日期：2021/03/30
产品编号：S0757
产品名称：(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole Fulvene-5
CAS编号：1075723-01-1
包装：5mg
价格：3251.43元

更新日期：2021/03/30
产品编号：S0757
产品名称：(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole Fulvene-5
CAS编号：1075723-01-1
包装：25mg
价格：9819.81元

(2E)-3-cyclopenta-2,4-dien-1-ylidene-2-(3-cyclopenta-2,4-dien-1-ylidene-1H-indol-2-ylidene)-1H-indole生产厂家