N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯

Z-WEHD-FMK (80 μM; 9 hours) elicits a near-complete blockage of C. trachomatis -induced cleavage of golgin-84 and increases GM130 expression in cells.Z-WEHD-FMK (30 min before being exposed to E. piscicida ) effectively inhibits 0909I E. piscicida induced ZF4 cells cytotoxicity and pyroptotic morphology. And in addition, it also inhibits the cytotoxicity induced by cytosolic LPS delivery.Z-WEHD-FMK (20 μM;18-24 hours following Cr ³⁺ ,Ni ²⁺ , and Co ²⁺ ) significantly induces a decrease of 76% to 86% in IL-1β release with 200 to 400 ppm Cr ³⁺ , it also induces a decrease of 35% to 45% with 48 ppm Ni ²⁺ or higher, Finally, this caspase-1 inhibitor induced a decrease with 6 ppm Co ²⁺ , down to a level below the detection threshold, and a decrease of 40% to 48% with 12 to 24 ppm Co ²⁺ in bone marrow-derived macrophages (BMDM).