5-(苄基硫代)-N-甲基-1,3,4-噻二唑-2-胺
- CAS号:65373-29-7
- 英文名:5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE
- 中文名:5-(苄基硫代)-N-甲基-1,3,4-噻二唑-2-胺
- CBNumber:CB8380663
- 分子式:C10H11N3S2
- 分子量:237.34
- MOL File:Mol file
- 沸点 :389.6±35.0 °C(Predicted)
- 密度 :1.31±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : 125 mg/mL (526.67 mM)
- 形态 :Solid
- 酸度系数(pKa) :2.67±0.10(Predicted)
- 颜色 :White to off-white
- 危险等级 :IRRITANT
5-(苄基硫代)-N-甲基-1,3,4-噻二唑-2-胺性质、用途与生产工艺
- 生物活性 MS21570 是 GPR171 的选择性拮抗剂，其 IC50 值为 220 nM。
-
靶点
IC50: 220 nM (GPR171).
-
体内研究
MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist.
- 更新日期：2024/11/08
- 产品编号：HY-112620
- 产品名称：MS21570
- CAS编号：
- 包装：5 mg
- 价格：562元
- 更新日期：2024/11/08
- 产品编号：HY-112620
- 产品名称：5-(苄基硫代)-N-甲基-1,3,4-噻二唑-2-胺 MS21570
- CAS编号：65373-29-7
- 包装：10mg
- 价格：900元
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
- 公司名称：ZERENEX
- 联系电话：--
- 电子邮件：sales@zerenex-molecular.com
- 国家：英国
- 产品数：6204
- 优势度：47
