ChemicalBook CAS数据库列表 1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE化学性质

熔点 :141-144 °C
沸点 :484.0±55.0 °C(Predicted)
密度 :1.29±0.1 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMF:30.0(Max Conc. mg/mL);81.89(Max Conc. mM)
DMSO:44.0(Max Conc. mg/mL);120.11(Max Conc. mM)
Ethanol:7.0(Max Conc. mg/mL);19.11(Max Conc. mM)
形态 :A solid
酸度系数(pKa) :-0.36±0.20(Predicted)
颜色 :Yellow to orange

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE性质、用途与生产工艺

生物活性 HT-2157(SNAP 37889) 是一种选择性的高亲和力甘丙肽-3 受体 (Gal3) 竞争性拮抗剂。
靶点

Galanin-3 receptor
体外研究

HT-2157 (SNAP 37889) binds with high affinity to membranes from transiently transfected LMTK ^- cells expressing the human Gal ₃ receptor (K _i =17.44±0.01 nM; n>100) and is highly selective for Gal ₃ over the Gal ₁ and Gal ₂ subtypes (K _i >10,000 nM for each subtype; n=46 of each subtype). When tested for the antagonism of galanin-evoked inhibition of adenylyl cyclase, HT-2157 (0.1-10 μM) produces concentration-dependent rightward shifts of the concentration-effect curve to galanin.
体内研究

The galanin-3 receptor antagonist, HT-2157 (SNAP 37889), reduces operant responding for ethanol in alcohol-preferring rats. The novel selective GALR3 antagonist, HT-2157, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. Male iP rats treated with HT-2157 at a dose of 30 mg/kg (i.p.) do not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with HT-2157 (30 mg/kg, i.p.) reduces operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study shows that HT-2157 (30 mg/kg, i.p.) is effective in reducing operant responding for ethanol, independent of a sedative effect.

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE上下游产品信息

上游原料

下游产品

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE生产厂家