生物活性 靶点 体外研究 体内研究 N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE 试剂级价格
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ChemicalBook  CAS数据库列表  N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE

N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE

生物活性 靶点 体外研究 体内研究 N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE 试剂级价格
N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE,1428327-31-4,结构式
N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
  • CAS号:1428327-31-4
  • 英文名:N-((4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide
  • 中文名:N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE
  • CBNumber:CB83146923
  • 分子式:C28H32N4O2S
  • 分子量:488.64
  • MOL File:1428327-31-4.mol
N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE化学性质
  • 储存条件 :2-8°C
  • 溶解度 :DMF:30.0(Max Conc. mg/mL);61.39(Max Conc. mM)
    DMSO:59.62(Max Conc. mg/mL);122.01(Max Conc. mM)
    DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM)
    Ethanol:12.5(Max Conc. mg/mL);25.58(Max Conc. mM)
  • 形态 :powder
  • 颜色 :white to beige

N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE性质、用途与生产工艺

  • 生物活性 JNJ-47965567 是一种中枢通透性、高亲和力、选择性的 P2X7 拮抗剂，对人和大鼠 P2X7 作用的 pKi 值分别为 7.9 和 8.7。JNJ-47965567 可用于探讨中枢 P2X7 在中枢神经系统病理生理模型中的作用。
  • 靶点

    pKi: 7.9 (huaman P2X7), 8.7 (rat P2X7)

  • 体外研究

    JNJ-47965567 exhibits high affinity for human and rat P2X7 in membrane preparations of 1321N1 cells.
    JNJ-47965567 does not block IL-6 and TNF-α release, under identical conditions (LPS and BZ-ATP) used for IL-1β and IL-18 release.
    JNJ-47965567 attenuates IL-1β release with pIC 50 s of 6.7 ± 0.07 (human blood), 7.5 ± 0.07 (human monocytes) and 7.1 ± 0.1 (rat microglia), respectively, in native systems.

  • 体内研究

    JNJ-47965567 (30-100 mg/kg; s.c.) attenuates IL-1β release induced by Bz-ATP.
    JNJ-47965567 (30 mg/kg) attenuates amphetamine-induced hyperactivity and exhibits modest, yet significant efficacy in the rat model of neuropathic pain.

    Animal Model: Male Sprague Dawley rats
    Dosage: 30 mg/kg, 100 mg/kg
    Administration: Subcutaneous injection; 30 minutes prior to Bz-ATP infusion
    Result: Significantly attenuated IL-1β release at 100 mg/kg, with no effect at 30 mg/kg dose group.
N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE上下游产品信息
上游原料
下游产品
N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-101418
  • 产品名称：JNJ-47965567
  • CAS编号：
  • 包装：1 mg
  • 价格：400元
  • 更新日期：2024/11/08
  • 产品编号：HY-101418
  • 产品名称：N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE JNJ-47965567
  • CAS编号：1428327-31-4
  • 包装：5mg
  • 价格：750元
N-[[4-(4-PHENYLPIPERAZIN-1-YL)OXAN-4-YL]METHYL]-2-PHENYLSULFANYLPYRIDINE-3-CARBOXAMIDE生产厂家
  • 公司名称：TOCRIS-US
  • 联系电话：--
  • 电子邮件：customerservice@tocris.co.uk
  • 国家：英国
  • 产品数：5726
  • 优势度：77
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