Amyloid beta-peptide (1-40) rat

生物活性靶点

Amyloid beta-peptide (1-40) rat化学性质

储存条件 :-15°C
溶解度 :Soluble to 1 mg/ml in 1% Ammonia
形态 :Solid
颜色 :White to off-white
序列 :H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

Amyloid beta-peptide (1-40) rat性质、用途与生产工艺

生物活性 Amyloid β-peptide (1-40) (rat) 是蛋白水解切割淀粉样蛋白前体蛋白的易聚集产物，并且是在阿尔茨海默病脑中观察到的老年斑的主要成分。
靶点

The Amyloid β-peptide (1-40) (rat)-treated rats require longer to find the platform hidden under the water. In the visible platform test, the latency for each group is similar (20.56±11.31 s in control and 14.68±9.97 s in Amyloid β-peptide (1-40) (rat) group, p=0.304). Among these tested proteins, 6 ones are significantly up-regulated and 7 ones significantly down-regulated in Amyloid β-peptide (1-40) (rat) group comparing with the control. Tubulin β chain is significantly down-regulated in Amyloid β-peptide (1-40) (rat) group (p=0.014) when compare with control. Similar changes are also observed for ATP synthase β subunit (p=0.010) and synapsin Ib between Amyloid β-peptide (1-40) (rat) and control groups, but not significantly for synapsin Ib (p=0.295).
多肽 Amyloid beta-peptide (1-40) rat是一种由淀粉样前体蛋白裂解后产生的一种容易聚集的多肽产物。在一些的动物实验中，Amyloid β-Protein (1-40) (mouse, rat)是阿尔茨海默病脑内老年斑块的主要组成部分。
参考质量标准外观:白色粉末
纯度(HPLC) ≥95.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥70.0%

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