N-[[反式-4-[[(4-氨基-2-喹唑啉基)氨基]甲基]环己基]甲基]-1-萘磺酰胺盐酸盐

N-[[反式-4-[[(4-氨基-2-喹唑啉基)氨基]甲基]环己基]甲基]-1-萘磺酰胺盐酸盐化学性质

安全信息

N-[[反式-4-[[(4-氨基-2-喹唑啉基)氨基]甲基]环己基]甲基]-1-萘磺酰胺盐酸盐性质、用途与生产工艺

生物活性 CGP71683 hydrochloride (CGP71683A) 是一种竞争性的、选择性 neuropeptide Y receptor type 5 (Y5 receptor) 拮抗剂，其Ki值为1.3 nM。
靶点
Target Value
Y5 receptor
(Cell-free assay) 1.3 nM(Ki)
体外研究

CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a K _i of 1.3 nM, and shows no obvious activity at Y1 receptor (K _i , >4000 nM) and Y2 receptor (K _i , 200 nM) in cell membranes.
体内研究

CGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats.

N-[[反式-4-[[(4-氨基-2-喹唑啉基)氨基]甲基]环己基]甲基]-1-萘磺酰胺盐酸盐上下游产品信息

上游原料

下游产品

N-[[反式-4-[[(4-氨基-2-喹唑啉基)氨基]甲基]环己基]甲基]-1-萘磺酰胺盐酸盐生产厂家

Target	Value
Y5 receptor (Cell-free assay)	1.3 nM(Ki)