Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
- CAS号:68027-15-6
- 英文名:Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
- 中文名:Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
- CBNumber:CB82645784
- 分子式:C47H76O17
- 分子量:913.09614
- MOL File:68027-15-6.mol
- 熔点 :239-241℃
- 沸点 :997.6±65.0 °C(Predicted)
- 密度 :1.40±0.1 g/cm3 (20 ºC 760 Torr)
- 储存条件 :Hygroscopic, -20°C Freezer, Under inert atmosphere
- 溶解度 :Methanol (Slightly), Pyridine
- 酸度系数(pKa) :4.63±0.70(Predicted)
- 形态 :Solid
- 颜色 :White to Light Beige
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside性质、用途与生产工艺
- 生物活性 Pulsatilla saponin D (SB365) 可从 Pulsatilla koreana Nakai 根部分离得到，具有抗癌活性。
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靶点
Target Value c-Met
() -
体外研究
Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase.
Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells.
Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) .
Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF.
Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells.Cell Cytotoxicity Assay
Cell Line: A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells. Concentration: 0.3 ng/mL to 10 μg/mL. Incubation Time: 72 h. Result: Exhibited an ED 50 value of 6.3 μg/mL for A-549 cells. -
体内研究
Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model.
Animal Model: 2x2x2 mm 3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice. Dosage: 6.4 mg/kg. Administration: Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. Result: Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). - 化学性质 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白头翁。
- 用途 白头翁皂苷D具有抗菌，抗肿瘤，镇静，镇痛的作用。
- 用途 药理药效:抗菌，抗肿瘤，镇静，镇痛
- 更新日期：2024/11/08
- 产品编号：S9308
- 产品名称：Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Pulsatilla saponin D
- CAS编号：68027-15-6
- 包装：1mg
- 价格：1286.58元
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
- N-乙酰基-D-乳糖胺 3-O-Β-D-葡萄糖( 1→4)-[ A -L-鼠李糖(1→2)]- A-L-阿拉伯糖 常春藤配基- 28-O-鼠李糖(1→4)葡萄糖(1→6)葡萄糖苷 HEDERACOLCHISIDE E 3-O-B-D-葡萄糖( 1→4)-[ A -L-鼠李糖(1→2)]- A-L-阿拉伯糖 23-羟基羽扇豆20(29)-烯-28–酸- 28-O-鼠李糖(1→4)葡萄糖(1→6)葡萄糖苷 牡丹草苷B(标准品) HEDERACOLCHISIDE A1; 白头翁皂甙 B4 LUP-20(29)-EN-28-OIC ACID, 3-[Β-D-GLUCOPYRANOSYL(1→4)[A-L-RHAMNOPYRANOSYL) (1→2)-A -L-ARABINOPYRANOSYL]OXY], (3Β,4A)-) 白头翁皂苷B 白头翁皂苷A3
