生物活性 靶点 体外研究 体内研究 Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside 试剂级价格
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ChemicalBook  CAS数据库列表  Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside

Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside

生物活性 靶点 体外研究 体内研究 Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside 试剂级价格
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside,68027-15-6,结构式
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
  • CAS号:68027-15-6
  • 英文名:Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
  • 中文名:Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
  • CBNumber:CB82645784
  • 分子式:C47H76O17
  • 分子量:913.09614
  • MOL File:68027-15-6.mol
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside化学性质
  • 熔点 :239-241℃
  • 沸点 :997.6±65.0 °C(Predicted)
  • 密度 :1.40±0.1 g/cm3 (20 ºC 760 Torr)
  • 储存条件 :Hygroscopic, -20°C Freezer, Under inert atmosphere
  • 溶解度 :Methanol (Slightly), Pyridine
  • 酸度系数(pKa) :4.63±0.70(Predicted)
  • 形态 :Solid
  • 颜色 :White to Light Beige

Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside性质、用途与生产工艺

  • 生物活性 Pulsatilla saponin D (SB365) 可从 Pulsatilla koreana Nakai 根部分离得到，具有抗癌活性。
  • 靶点
    TargetValue
    c-Met
    ()
  • 体外研究

    Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase.
    Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells.
    Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) .
    Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF.
    Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells.

    Cell Cytotoxicity Assay

    Cell Line: A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells.
    Concentration: 0.3 ng/mL to 10 μg/mL.
    Incubation Time: 72 h.
    Result: Exhibited an ED 50 value of 6.3 μg/mL for A-549 cells.
  • 体内研究

    Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model.

    Animal Model: 2x2x2 mm 3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice.
    Dosage: 6.4 mg/kg.
    Administration: Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day.
    Result: Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).
  • 化学性质  白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白头翁。
  • 用途  白头翁皂苷D具有抗菌，抗肿瘤，镇静，镇痛的作用。
  • 用途  药理药效:抗菌，抗肿瘤，镇静，镇痛
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside上下游产品信息
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下游产品
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：S9308
  • 产品名称：Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Pulsatilla saponin D
  • CAS编号：68027-15-6
  • 包装：1mg
  • 价格：1286.58元
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside生产厂家
  • 公司名称：MedChemexpress LLC
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