ChemicalBook CAS数据库列表 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
![1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE,1125758-85-1,结构式](https://www.chemicalbook.com/CAS/20180713/GIF/1125758-85-1.gif)
- CAS号:1125758-85-1
- 英文名:A 804598
- 中文名:1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
- CBNumber:CB82602998
- 分子式:C19H17N5
- 分子量:315.37
- MOL File:1125758-85-1.mol
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE化学性质
- 沸点 :498.0±47.0 °C(Predicted)
- 密度 :1.17±0.1 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Sealed in dry,2-8°C
- 溶解度 :DMSO: soluble10mg/mL, clear
- 酸度系数(pKa) :4.52±0.12(Predicted)
- 形态 :powder
- 颜色 :white to beige
安全信息
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE性质、用途与生产工艺
- 生物活性 A-804598 是一个 CNS 渗透，竞争性和选择性的 P2X7 受体拮抗剂，作用于小鼠，大鼠和人的 P2X7 受体，IC50s 分别是 9 nM, 10 nM 和 11 nM。
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靶点
IC50: 9 nM (mouse P2X7 receptor), 10 nM (rat P2X7 receptor), 11 nM (human P2X7 receptor)
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体外研究
Pre-incubation with A-804598 (0.1-10 μM; 1 hour) significantly attenuates BzATP-induced cell loss in a concentration-dependent manner. 3 μM A-804598 exhibits the greatest protective effect against BzATP-induced cytotoxicity.
Cell Cytotoxicity Assay
Cell Line: microglial cell Concentration: 0.1, 0.3, 1, 3, 10 μM Incubation Time: 1 hour Result: Protected against BzATP-induced cytotoxicity in both inactivated and activated microglia. -
体内研究
A chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease.
Animal Model: Adult B6.Cg-Tg (SOD1-G93A) 1Gur/J female mice Dosage: 30 mg/kg Administration: Intraperitoneal injection; five times a week Result: Decreased SQSTM1/p62 expression.
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE上下游产品信息
上游原料
下游产品
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-100483
- 产品名称：A-804598
- CAS编号：
- 包装：1 mg
- 价格：300元
- 更新日期：2024/11/08
- 产品编号：HY-100483
- 产品名称：1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE A-804598
- CAS编号：1125758-85-1
- 包装：5mg
- 价格：550元
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE生产厂家
- 公司名称：Novachemistry
- 联系电话：44-20819178-90 02081917890
- 电子邮件：info@novachemistry.com
- 国家：英国
- 产品数：4381
- 优势度：58
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
