ChemicalBook CAS数据库列表 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物
4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物
- CAS号:915967-82-7
- 英文名:4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate
- 中文名:4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物
- CBNumber:CB82565923
- 分子式:C29H32Cl2N6.4(H3PO4).4(H2O)
- 分子量:651.521041
- MOL File:915967-82-7.mol
4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物化学性质
- 熔点 :252 °C(dec.)
- 储存条件 :room temp
- 溶解度 :H2O: ≥10mg/mL
- 形态 :Powder
- 颜色 :white to off-white
- 敏感性 :Hygroscopic
安全信息
4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物性质、用途与生产工艺
- 生物活性 Piperaquine tetraphosphate tetrahydrate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。
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体内研究
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.
Piperaquine (90 mg/kg; a single i.p.) exhibits the t 1/2 , apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.Animal Model: Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites Dosage: 0, 10, 30, 90 mg/kg Administration: A single i.p. administration Result: The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.Animal Model: Male Swiss mice (6 weeks old) Dosage: 90 mg/kg (Pharmacokinetic Analysis) Administration: A single i.p. administration Result: t 1/2 =17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.
4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物上下游产品信息
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下游产品
4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-B1896B
- 产品名称：4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物 Piperaquine tetraphosphate tetrahydrate
- CAS编号：915967-82-7
- 包装：5mg
- 价格：200元
- 更新日期：2024/11/08
- 产品编号：HY-B1896B
- 产品名称：4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物 Piperaquine tetraphosphate tetrahydrate
- CAS编号：915967-82-7
- 包装：10mg
- 价格：320元
4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物生产厂家
- 公司名称：TOKYO CHEMICAL INDUSTRY CO., LTD.
- 联系电话：03-36680489
- 电子邮件：Sales-JP@TCIchemicals.com
- 国家：日本
- 产品数：28387
- 优势度：80
