Unii-T4np8G3K6q
- CAS号:195533-53-0
- 英文名:Unii-T4np8G3K6q
- 中文名:Unii-T4np8G3K6q
- CBNumber:CB82494683
- 分子式:C13H7F6NO3S
- 分子量:371.26
- MOL File:195533-53-0.mol
- 沸点 :403.3±55.0 °C(Predicted)
- 密度 :1.629±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 100 mg/mL (269.35 mM)
- 形态 :Solid
- 酸度系数(pKa) :5.74±0.10(Predicted)
- 颜色 :White to off-white
Unii-T4np8G3K6q性质、用途与生产工艺
- 生物活性 Batabulin (T138067) 是一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管 (microtubule) 聚合。Batabulin 影响细胞形态并导致细胞周期停滞，最终诱导凋亡性细胞死亡。
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靶点
β-tubulin
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体外研究
Batabulin (T138067; 30-300 nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary.
Batabulin (T138067; 30-300 nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis.
Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy.Cell Cycle Analysis
Cell Line: MCF7 cells Concentration: 30 nM, 100 nM and 300 nM Incubation Time: 24 hours Result: Showed an arrest at the G2/M cell-cycle boundary. Apoptosis Analysis
Cell Line: MCF7 cells Concentration: 30 nM, 100 nM and 300 nM Incubation Time: 24 hours or 48 hours Result: 25-30% of cells showed the reduced DNA content characteristic of apoptotic cells. -
体内研究
Batabulin (T138067; 40 mg/kg; intraperitoneal injection; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors.
Animal Model: Male athymic nude mice ( nu/nu ) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells Dosage: 40 mg/kg Administration: Intraperitoneal injection; once per week; on days 5, 12, and 19 Result: Impaired the growth of the drug-sensitive CCRF-CEM tumors.
- 更新日期：2024/08/19
- 产品编号：HY-13563
- 产品名称：Batabulin
- CAS编号：
- 包装：1 mg
- 价格：550元
- 更新日期：2024/08/19
- 产品编号：HY-13563
- 产品名称：Unii-T4np8G3K6q Batabulin
- CAS编号：195533-53-0
- 包装：5mg
- 价格：1500元
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32038
- 优势度：58
- 公司名称：BOC Sciences
- 联系电话：+1-631-485-4226
- 电子邮件：inquiry@bocsci.com
- 国家：美国
- 产品数：19553
- 优势度：58
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：
- 电子邮件：support@targetmol.com
- 国家：美国
- 产品数：38463
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：52925
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
