ChemicalBook CAS数据库列表 8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT

8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT

生物活性靶点体外研究

CAS号:129693-13-6
英文名:8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT
中文名:
CBNumber:CB8246174
分子式:C16H14ClN5NaO5PS2
分子量:509.86
MOL File:129693-13-6.mol

8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT化学性质

安全信息

8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT性质、用途与生产工艺

生物活性 Sp-8-CPT-cAMPS，一种 cAMP 类似物，是 cAMP 依赖性蛋白激酶 A PKA I 和 PKA II 的有效和选择性的激活剂。Sp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。
靶点

PKA
体外研究

Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells.
Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells.
Sp-8-CPT-cAMPS (10 μM; 30 min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis.

8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT上下游产品信息

上游原料

下游产品

8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT生产厂家