吡咯烷二硫代甲酸铵盐

用途生物活性靶点体外研究体内研究吡咯烷二硫代甲酸铵盐试剂级价格

吡咯烷二硫代甲酸铵盐

CAS号:5108-96-3
英文名:Ammonium 1-pyrrolidinedithiocarbamate
中文名:吡咯烷二硫代甲酸铵盐
CBNumber:CB8216948
分子式:C5H9NS2.H3N
分子量:164.3
MOL File:5108-96-3.mol

吡咯烷二硫代甲酸铵盐化学性质

熔点 :153-155 °C(lit.)
密度 :1.117 (estimate)
折射率 :1.5300 (estimate)
储存条件 :Store at +2°C to +8°C.
溶解度 :190g/l
形态 :Powder/Solid
颜色 :White to off-white
PH值 :6-7 (50g/l, H2O, 20℃)
水溶解性 :50 g/L (20 ºC)
敏感性 :Hygroscopic
BRN :3730472
稳定性 :Stable. Incompatible with strong oxidizing agents.
CAS 数据库 :5108-96-3(CAS DataBase Reference)
EPA化学物质信息 :1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3)

安全信息

危险品标志 :Xi,Xn
危险类别码 :36/37/38-22
安全说明 :26-36-37/39
WGK Germany :3
F :3
TSCA :Yes
海关编码 :29339990

吡咯烷二硫代甲酸铵盐 MSDS

Ammonium 1-pyrrolidinedithiocarbamate

吡咯烷二硫代甲酸铵盐性质、用途与生产工艺

用途吡咯烷二硫代甲酸铵盐在包括金属螯合作用在内的生物化学应用中很有用。它被用来防止一氧化氮合酶的诱导。抑制白血病HL-60细胞的凋亡也是非常重要的。
生物活性 Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt)是NF-κB的有效抑制剂，抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。
靶点
Target Value
NF-κB
()
体外研究

Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.
体内研究

The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.