锌原卟啉
- CAS号:15442-64-5
- 英文名:PROTOPORPHYRINATO ZINC
- 中文名:锌原卟啉
- CBNumber:CB8208833
- 分子式:C34H31N4O4Zn-
- 分子量:625.03
- MOL File:15442-64-5.mol
- RTECS号 :ZG9210300
- 储存条件 :Inert atmosphere,2-8°C
- 溶解度 :DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- 形态 :Crystalline
- 颜色 :Dark red to purple
- 水溶解性 :Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide.
- 稳定性 :Hygroscopic
- EPA化学物质信息 :Zincate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-4-2)- (15442-64-5)
- WGK Germany :3
- TSCA :Yes
锌原卟啉性质、用途与生产工艺
- 生物活性 Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的，竞争性的血红素加氧酶-1 (HO-1) 抑制剂，显着减弱间苯三酚 (PG) 对 H2O2 的保护作用。Zinc Protoporphyrin 可用作个体孕妇和儿童缺铁的筛查标志物，也用于评估人群铁状态与血红蛋白浓度的组合。Zinc Protoporphyrin 具有抗癌活性。
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靶点
Human Endogenous Metabolite
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体外研究
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.
Apoptosis Analysis
Cell Line: C-26 cells Concentration: 5 μM Incubation Time: 72 hours Result: The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h. Cell Cytotoxicity Assay
Cell Line: C-26 and MDA-MB231 cells Concentration: 1.25, 2.5, 5, 10, 20, 40 μM Incubation Time: 48 or 72 hours Result: Exerted cystostatic/cytotoxic effects against tumor cells. Cell Cycle Analysis
Cell Line: C-26 cells Concentration: 2.5, 5 μM Incubation Time: 48 or 72 hours Result: Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle. Western Blot Analysis
Cell Line: C-26 cells Concentration: 1.25, 2.5, 5, 10, 20, 40 μM Incubation Time: 48 hours Result: Leaded to accumulation of cleaved (active) caspase-3. -
体内研究
Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.
Animal Model: BALB/c mice inoculated with C-26 cells Dosage: 12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o. Administration: IP or PO; from day 7 to 19 Result: Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.
- 更新日期：2024/11/08
- 产品编号：032068
- 产品名称：三水合原卟啉锌, 96% Zinc protoporphyrin, 96%
- CAS编号：15442-64-5
- 包装：10mg
- 价格：724元
- 更新日期：2024/11/08
- 产品编号：032068
- 产品名称：三水合原卟啉锌, 96% Zinc protoporphyrin, 96%
- CAS编号：15442-64-5
- 包装：50mg
- 价格：2048元
- 公司名称：ABCR
- 联系电话：--
- 电子邮件：info@abcr.de
- 国家：德国
- 产品数：6831
- 优势度：75
