BIMOSIAMOSE DISODIUM
- CAS号:187269-60-9
- 英文名:Bimosiamose disodium
- 中文名:BIMOSIAMOSE DISODIUM
- CBNumber:CB81401695
- 分子式:C46H52Na2O16
- 分子量:906.87502
- MOL File:187269-60-9.mol
- 熔点 :243-245°
BIMOSIAMOSE DISODIUM性质、用途与生产工艺
- 生物活性 Bimosiamose disodium (TBC-1269Z) 是一种非寡糖泛-selectin 抑制剂，对 E-selectin，P-selectin 和 L-selectin 的 IC50 分别为 88 μM，20 μM 和 86μM。Bimosiamose disodium 具有抗炎作用。
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靶点
IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)
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体外研究
Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.
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体内研究
Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.
Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R) Dosage: 25 mg/kg Administration: Intravenous injection Result: Showed a significant increase in survival compared with controls.
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