ChemicalBook CAS数据库列表 6-methyl-1,3,8-trichlorodibenzofuran
6-methyl-1,3,8-trichlorodibenzofuran
- CAS号:115039-00-4
- 英文名:6-methyl-1,3,8-trichlorodibenzofuran
- 中文名:6-methyl-1,3,8-trichlorodibenzofuran
- CBNumber:CB81333417
- 分子式:
- 分子量:0
- MOL File:115039-00-4.mol
6-methyl-1,3,8-trichlorodibenzofuran性质、用途与生产工艺
- 生物活性 AhR modulator-1 (compound 6-MCDF) 是一种选择性的口服活性芳烃受体 (AhR) 调节剂。AhR modulator-1 部分地通过在肿瘤形成之前抑制前列腺 VEGF 的产生而抑制肿瘤转移。AhR modulator-1 在大鼠子宫中也具有抗雌激素特性。
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靶点
Aryl hydrocarbon receptor (AhR)
Prostatic VEGF
Estrogenic -
体外研究
AhR modulator-1 (6-MCDF; 0.1-10 μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively.
Cell Proliferation Assay
Cell Line: ASPC-1 cells Concentration: 0.1 μM, 1 μM and 10 μM Incubation Time: 48 hours, 72 hours, 96 hours Result: Exhibited dose-dependent growth inhibitory effects. -
体内研究
AhR modulator-1 (6-MCDF; 0-40 mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced.
Animal Model: C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old) Dosage: 0 mg/kg, 10 mg/kg, 40 mg/kg Administration: Oral administration; daily; for 12 weeks Result: The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40 mg /kg diet.S erum VEGF concentrations were also reduced.
6-methyl-1,3,8-trichlorodibenzofuran上下游产品信息
上游原料
下游产品
6-methyl-1,3,8-trichlorodibenzofuran生产厂家
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：19892
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
