野菊花内酯
- CAS号:62687-22-3
- 英文名:handelin
- 中文名:野菊花内酯
- CBNumber:CB81326400
- 分子式:C32H40O8
- 分子量:552.66
- MOL File:62687-22-3.mol
- 沸点 :731.0±60.0 °C(Predicted)
- 密度 :1.34±0.1 g/cm3 (20 ºC 760 Torr)
- 形态 :Solid
- 酸度系数(pKa) :14.34±0.70(Predicted)
- 颜色 :White to off-white
野菊花内酯性质、用途与生产工艺
- 生物活性 Handelin 是来自Chrysanthemum boreale 的愈创木酚内酯二聚体，它通过下调 NF-κB 信号传导和促炎性细胞因子的产生而具有强大的抗炎活性。
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体外研究
Handelin (Compound 1; 10-40 μM; RAW 264.7 cells) treatment suppresses the LPS-induced (1 μg/mL) overexpression of iNOS and COX-2 protein levels in a concentration-dependent manner. Handelin also suppresseS the induction of pro-inflammatory cytokines TNF-α and IL-1β in LPS-stimulated RAW 264.7 cells. Handelin also suppresses the activation of mitogen-activated protein kinases, including ERK and JNK signaling.
Handelin (Compound 1; 10-40 μM; RAW 264.7 cells) treatment significantly reduces the iNOS and COX-2 mRNA levels in LPS- stimulated RAW 264.7 cells. The transcriptional activity of NF-κB stimulated with LPS is also suppressed by Handelin. In addition, the LPS-stimulated upregulation of miRNA-155 expression is suppressed by Handelin.RT-PCR
Cell Line: RAW 264.7 cells Concentration: 10 μM, 20 μM, 40 μM Incubation Time: 5 hours Result: iNOS and COX-2 mRNA levels were significantly reduced. The transcriptional activity of NF-κB stimulated with LPS was also suppressed and the LPS-stimulated upregulation of miRNA-155 expression was also suppressed. Western Blot Analysis
Cell Line: RAW 264.7 cells Concentration: 10 μM, 20 μM, 40 μM Incubation Time: Result: Suppressed the LPS-induced overexpression of iNOS and COX-2 protein levels in a concentration-dependent manner. Suppressed the induction of pro-inflammatory cytokines TNF-α and IL-1β, and also also suppressed the activation of mitogen-activated protein kinases, including ERK and JNK signaling in LPS-stimulated RAW 264.7 cells. -
体内研究
Handelin (Compound 1; 10-20 mg/kg; oral administration; for 30 mintues; male Sprague-Dawley rats) treatment inhibits acute inflammation in carrageenan-induced paw edema model. The serum level of IL-1β is also inhibited by Handelin in a carrageenan-induced paw edema model .
Animal Model: Male Sprague-Dawley (SD) rats (150-170 g, 5 weeks old) injected with carrageenan Dosage: 10 mg/kg, 20 mg/kg Administration: Oral administration; for 30 mintues Result: Inhibited acute inflammation in carrageenan-induced paw. The serum level of IL-1β was also inhibited. - 化学性质 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于野菊花。
- 用途 野菊花内酯具有清热解毒，消肿，降压的作用。
- 用途 用于含量测定/鉴定/药理实验等。
- 更新日期：2024/04/30
- 产品编号：HY-N2083
- 产品名称：Handelin
- CAS编号：
- 包装：1 mg
- 价格：1024元
- 更新日期：2024/04/30
- 产品编号：HY-N2083
- 产品名称：野菊花内酯 Handelin
- CAS编号：62687-22-3
- 包装：5mg
- 价格：2200元
- 公司名称：ALB Technology Limited
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