双(麦芽醇)氧钒(IV)

生物活性靶点体外研究体内研究双(麦芽醇)氧钒(IV) 试剂级价格

双(麦芽醇)氧钒(IV)

CAS号:38213-69-3
英文名:Bis(maltolato)oxovanadium(IV)
中文名:双(麦芽醇)氧钒(IV)
CBNumber:CB8113685
分子式:C12H10O7V
分子量:317.15
MOL File:38213-69-3.mol

双(麦芽醇)氧钒(IV)化学性质

熔点 :>300°C (dec.)
储存条件 :Refrigerator
溶解度 :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
形态 :powder
颜色 :yellow to grey to brown
LogP :0.079 (est)

安全信息

危险品运输编号 :UN 2811 6.1 / PGIII
WGK Germany :3

双(麦芽醇)氧钒(IV)性质、用途与生产工艺

生物活性 BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV))是一种有效的口服钒复合物，具有抗糖尿病特性和模仿胰岛素的作用。BMOV被证明可改善糖尿病模型的心脏功能障碍。
靶点

IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)
体外研究

Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells.

体内研究

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice.

Animal Model:	C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)
Dosage:	0.75-3.0 mmol
Administration:	Intraperitoneal injection; twice weekly; for 6 weeks
Result:	Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.