ChemicalBook CAS数据库列表 双(麦芽醇)氧钒(IV)
双(麦芽醇)氧钒(IV)
- CAS号:38213-69-3
- 英文名:Bis(maltolato)oxovanadium(IV)
- 中文名:双(麦芽醇)氧钒(IV)
- CBNumber:CB8113685
- 分子式:C12H10O7V
- 分子量:317.15
- MOL File:38213-69-3.mol
双(麦芽醇)氧钒(IV)化学性质
- 熔点 :>300°C (dec.)
- 储存条件 :Refrigerator
- 溶解度 :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- 形态 :powder
- 颜色 :yellow to grey to brown
- LogP :0.079 (est)
安全信息
- 危险品运输编号 :UN 2811 6.1 / PGIII
- WGK Germany :3
双(麦芽醇)氧钒(IV)性质、用途与生产工艺
- 生物活性 BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV))是一种有效的口服钒复合物，具有抗糖尿病特性和模仿胰岛素的作用。BMOV被证明可改善糖尿病模型的心脏功能障碍。
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靶点
IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)
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体外研究
Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells.
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体内研究
Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice.
Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD) Dosage: 0.75-3.0 mmol Administration: Intraperitoneal injection; twice weekly; for 6 weeks Result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
双(麦芽醇)氧钒(IV)上下游产品信息
上游原料
下游产品
双(麦芽醇)氧钒(IV) 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-118567
- 产品名称：Bis(maltolato)oxovanadium(IV)
- CAS编号：
- 包装：5 mg
- 价格：400元
- 更新日期：2024/11/08
- 产品编号：HY-118567
- 产品名称：Bis(maltolato)oxovanadium(IV)
- CAS编号：
- 包装：10 mM * 1 mLin DMSO
- 价格：440元
双(麦芽醇)氧钒(IV)生产厂家
- 公司名称：WAKO
- 联系电话：--
- 电子邮件：labchem-tec@wako-chem.co.jp
- 国家：日本
- 产品数：6819
- 优势度：80
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