ChemicalBook CAS数据库列表 Zamifenacinfumarate
Zamifenacinfumarate
- CAS号:127308-98-9
- 英文名:Zamifenacinfumarate
- 中文名:Zamifenacinfumarate
- CBNumber:CB81075168
- 分子式:C31H33NO7
- 分子量:531.61
- MOL File:127308-98-9.mol
Zamifenacinfumarate化学性质
- 储存条件 :Inert atmosphere,2-8°C
- 溶解度 :Soluble to 100 mM in DMSO and to 25 mM in ethanol
- 形态 :Powder
- 颜色 :White to off-white
Zamifenacinfumarate性质、用途与生产工艺
- 生物活性 Zamifenacin fumarate (UK-76654 fumarate) 是一种有效的肠道选择性毒蕈碱 M3 受体拮抗剂。Zamifenacin 可显着降低肠易激综合症的结肠蠕动。
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靶点
Muscarinic M3 receptor
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体内研究
Zamifenacin exhibits moderate oral bioavailability (mouse 26%, rat 64%, dog 100%) and C max (mouse 92, rat 905, dog 416 ng/mL) following oral administration (mouse 13.2, rat 20 and, dog 5 mg/kg).
Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg).Animal Model: Male CDl mice (mean weight 23 g) Dosage: 5.3 mg/kg for i.v.; 13.2 mg/kg for oral (Pharmacokinetic Analysis) Administration: Intravenous administration and oral administration Result: Oral bioavailability (26%), C max (92 ng/mL), T 1/2 (1.1 h). Animal Model: Male and female CD rats (mean weight 210 g) Dosage: 5.0 mg/kg for i.v.; 20 mg/kg for oral (Pharmacokinetic Analysis) Administration: Intravenous administration and oral administration Result: Oral bioavailability (64%), C max (905 ng/mL), T 1/2 (6.0 h). Animal Model: Male and two female beagle dogs (13-16 kg) Dosage: 1.0 mg/kg for i.v.; 5 mg/kg for oral (Pharmacokinetic Analysis) Administration: Intravenous administration and oral administration Result: Oral bioavailability (100%), C max (416 ng/mL), T 1/2 (1.1 h).
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Zamifenacinfumarate 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-107649
- 产品名称：Zamifenacinfumarate Zamifenacin fumarate
- CAS编号：127308-98-9
- 包装：5mg
- 价格：1000元
- 更新日期：2024/11/08
- 产品编号：HY-107649
- 产品名称：Zamifenacinfumarate Zamifenacin fumarate
- CAS编号：127308-98-9
- 包装：10mM * 1mLin DMSO
- 价格：1170元
Zamifenacinfumarate生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
