丹酚酸B镁盐
- CAS号:122021-74-3
- 英文名:magnessium lithospermate B
- 中文名:丹酚酸B镁盐
- CBNumber:CB7980918
- 分子式:C36H28MgO16
- 分子量:740.90292
- MOL File:122021-74-3.mol
- 溶解度 :Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- 形态 :Powder
- 颜色 :Light yellow to light brown
丹酚酸B镁盐性质、用途与生产工艺
- 生物活性 Magnesium Lithospermate B 是从 Salviae miltiorrhizae 中提取的咖啡酸四聚体的衍生物。Magnesium Lithospermate B 被广泛用于心血管疾病的研究，并且可以防止葡萄糖引起的细胞内氧化损伤。Magnesium Lithospermate B 还能够抑制神经炎症并减轻神经变性。
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体外研究
Magnesium Lithospermate B (20-60 μg/ml; 24 h) decreases LDH activity in the cultured supernatant, increases SOD activity in cardiomyocytes, reduces intracellular ROS and MDA levels, and significantly suppresses cardiomyocytes apoptosis.
Magnesium Lithospermate B (1-100 μg/ml) enhances proliferation of neural stem cells (NSCs) in a dose-dependent manner.
Magnesium Lithospermate B (10 μg/ml) promotes the differentiation in vitro of NSCs towards neurons. -
体内研究
Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats.
Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models.Animal Model: Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats Dosage: 2, 8 mg/kg Administration: P.o. once daily for 16 days Result: Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase.
Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21.
- 更新日期：2024/11/08
- 产品编号：HY-126415
- 产品名称：丹酚酸B镁盐 Magnesium Lithospermate B
- CAS编号：
- 包装：5 mg
- 价格：950元
- 更新日期：2024/11/08
- 产品编号：HY-126415
- 产品名称：丹酚酸B镁盐 Magnesium Lithospermate B
- CAS编号：
- 包装：10 mg
- 价格：1500元
- 公司名称：EMMX Biotechnology LLC
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